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. 2020 Jan 31;11:61. doi: 10.3389/fmicb.2020.00061

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Copyright © 2020 An, Han, Zhao, English, Frost, Zhang and Shang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The study flowchart used to screen and identify HIV-1 CRF01_AE strains associated with viral transmission in China. The Blast tool was used to search the sequence of interest in (i) the Los Alamos HIV sequence database and (ii) the United Kingdom HIV Drug Resistance Database. Five published Chinese major CRF01_AE clusters were used as queries (covering protease and partial reverse transcriptase nucleotide sequences). The top 200 sequences were selected and included in this analysis according to Blast scores. Phylogenetic and phylogeographic analyses were reconstructed to identify the relationship between Chinese CRF01_AE and CRF01_AE from other countries/regions globally.