Table 1.

Enriched genesets in MM HDNs using GSEA analysis.

MM HDN	SIZE	ES	NES	NOM p-val	FDR q-val	FWER p-val	RANK AT MAX	LEADING EDGE
HALLMARK_INTERFERON_ALPHA_RESPONSE	96	−0.75	−2.20	0.00	<0.0001	<0.0001	3954	tags = 63%, list = 12%, signal = 71%
HALLMARK_INTERFERON_GAMMA_RESPONSE	199	−0.63	−2.01	0.00	<0.0001	<0.0001	3954	tags = 51%, list = 12%, signal = 58%
HALLMARK_IL6_JAK_STAT3_SIGNALING	87	−0.67	−1.95	0.00	<0.0001	<0.0001	4482	tags = 46%, list = 13%, signal = 53%
HALLMARK_INFLAMMATORY_RESPONSE	199	−0.56	−1.80	0.00	<0.0001	<0.0001	4860	tags = 37%, list = 14%, signal = 43%
HALLMARK_PI3K_AKT_MTOR_SIGNALING	104	−0.58	−1.74	0.00	<0.0001	<0.0001	3946	tags = 34%, list = 12%, signal = 38%
HALLMARK_PROTEIN_SECRETION	96	−0.56	−1.66	0.00	<0.0001	0.01	3723	tags = 42%, list = 11%, signal = 47%
HALLMARK_APICAL_JUNCTION	199	−0.51	−1.63	0.00	<0.0001	0.02	4298	tags = 26%, list = 13%, signal = 29%
HALLMARK_MITOTIC_SPINDLE	197	−0.51	−1.62	0.00	<0.0001	0.02	4356	tags = 31%, list = 13%, signal = 35%
HALLMARK_KRAS_SIGNALING_UP	200	−0.50	−1.61	0.00	0.01	0.04	3185	tags = 22%, list = 9%, signal = 24%

Abbreviations: FWER, family-wise error rate; NOM, nominal.

The top enriched genesets as ranked by NES are shown for Hallmark genesets.