Table 2.
Dosimetric calculations of 177Lu-PSMA-617 therapy compared to SUVmax values
| Skeletal metastases | Lymph node metastases | Visceral metastases | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Absorbed dose | SUVmax | Absorbed dose | SUVmax | Absorbed dose | SUVmax | ||||||||||||
| Patient | Therapy cycles | Accumulated activity (GBq) | D/Aa(Gy/GBq) | Dtotb(Gy) | Baseline | After 2 cycles | After 3/4 cycles | D/A1(Gy/GBq) | Dtot2 (Gy) | Baseline | After 2 cycles | After 3/4 cycles | D/A1(Gy/GBq) | Dtot2 (Gy) | Baseline | After 2 cycles | After 3/4 cycles |
| 1 | 3 | 17.7 | 1.70 | 30.16 | 12.40 | 9.10 | 7.20 | np | np | 16.50 | 3.33 | 7.93 | / | / | / | / | / |
| 2 | 3 | 19.3 | 3.68 | 71.17 | 21.53 | 8.40 | / | / | / | / | / | / | / | / | / | / | / |
| 3 | 3 | 18.6 | 3.12 | 58.13 | 18.12 | 11.00 | 11.97 | np | np | 20.88 | 4.60 | 2.95 | / | / | / | / | / |
| 4 | 3 | 16.3 | 2.30 | 37.49 | 8.00 | 5.40 | 5.49 | / | / | / | / | / | / | / | / | / | / |
| 5 | 3 | 17.9 | 5.90 | 105.49 | 15.00 | 6.40 | 8.70 | / | / | 4.10 | 1.20 | 1.10 | / | / | / | / | / |
| 6 | 3 | 18.1 | 1.70 | 30.80 | 30.37 | 28.87 | 22.07 | 2.85 | 51.64 | 16.00 | 21.80 | 22.50 | 1.70 | 30.80 | 28.55 | 34.25 | 24.70 |
| 7 | 3 | 18.8 | 7.50 | 141.23 | 27.65 | 18.83 | 14.10 | / | / | / | / | / | 3.25 | 61.20 | 16.90 | 12.20 | 14.60 |
| 8 | 2 | 12.7 | 4.95 | 62.87 | 9.99 | 12.79 | / | / | / | / | / | / | / | / | / | / | / |
| 9 | 3 | 18.6 | 1.10 | 20.45 | 28.93 | 15.63 | / | / | / | / | / | / | 2.35 | 43.69 | 24.10 | 17.75 | / |
| 10 | 4 + 2 | 24.3 | 2.80 | 68.04 | 18.99 | 13.32 | 9.21 | 2.25 | 54.68 | 21.43 | 12.48 | np | / | / | / | / | / |
| 11 | 4 + 2 | 25.6 | 4.19 | 107.31 | 7.10 | 15.10 | 10.30 | 3.60 | 92.20 | 66.40 | 4.80 | 8.80 | / | / | / | / | / |
| 12 | 2 | 12.8 | 1.39 | 17.78 | 15.00 | 7.10 | / | 1.72 | 22.00 | 16.70 | 8.00 | / | / | / | / | / | / |
| 13 | 4 | 25.3 | 3.40 | 86.09 | 22.10 | / | 12.50 | 6.20 | 156.98 | 66.30 | / | 29.30 | 4.30 | 108.88 | 37.90 | / | 15.40 |
| 14 | 4 | 24.9 | / | / | / | / | / | 1.90 | 47.31 | 18.20 | / | / | np | np | 2.50 | / | / |
| 15 | 3 | 18.3 | / | / | 11.20 | 21.40 | 6.80 | 2.08 | 38.04 | 10.20 | 28.70 | 19.60 | / | / | / | / | / |
| 16 | 4 | 23.3 | 4.00 | 93.36 | 31.00 | / | / | / | / | / | / | / | / | / | / | / | / |
| 17 | 4 | 24.9 | / | / | / | / | / | 4.00 | 99.60 | 65.20 | / | 16.10 | / | / | / | / | / |
| 18 | 3 | 18.1 | / | / | / | / | / | / | / | / | / | / | 3.60 | 65.16 | 19.30 | / | 14.00 |
| 19 | 4 | 24.4 | 13.00 | 317.20 | 37.50 | / | 4.80 | / | / | / | / | / | 5.00 | 122.00 | 14.15 | 12.20 | 10.85 |
| 20 | 4 + 2 | 37.13 | / | / | / | / | / | 3.00 | 111.39 | 21.60 | / | 8.60 | / | / | / | / | / |
| 21 | 2 | 10.8 | 6.40 | 68.86 | 22.40 | 20.10 | / | 8.70 | 93.61 | 106.60 | 61.40 | / | / | / | / | / | / |
| 22 | 4 | 23.8 | / | / | / | / | / | 2.90 | 69.02 | 39.80 | 5.40 | 3.20 | / | / | / | / | / |
| 23 | 4 | 24.6 | 2.37 | 58.30 | 57.27 | / | 16.30 | / | / | / | / | / | 2.80 | 68.88 | 22.66 | / | 17.31 |
| 24 | 4 | 25.3 | 6.00 | 151.62 | 5.00 | / | 3.40 | 2.00 | 50.60 | 10.00 | / | 7.80 | / | / | / | / | / |
| 25 | 4 | 24.4 | 6.66 | 162.37 | 36.40 | / | / | / | / | 37.80 | / | / | / | / | / | / | / |
| 26 | 4 | 25.3 | 3.72 | 94.26 | 29.20 | / | 2.20 | np | np | 15.90 | / | 3.30 | np | np | 17.30 | / | 11.80 |
| 27 | 3 | 19.0 | / | / | / | / | / | 0.70 | 13.30 | 15.90 | / | / | 0.76 | 14.44 | 16.50 | / | / |
| 28 | 4 + 1 | 25.0 | 3.70 | 92.50 | 15.70 | / | 12.00 | np | np | 10.13 | / | 5.57 | np | np | / | / | / |
| 29 | 3 | 16.0 | / | / | / | / | / | 1.80 | 28.87 | 18.90 | / | 24.20 | / | / | / | / | / |
| 30 | 4 | 25.5 | 3.20 | 81.60 | 12.79 | / | 3.35 | np | np | 9.25 | / | 1.21 | / | / | / | / | / |
| 31 | 4 | 23.7 | 1.25 | 18.96 | 41.06 | / | 7.70 | 6.30 | 149.31 | 44.15 | / | 14.54 | / | / | / | / | / |
| 32 | 4 | 21.5 | 2.10 | 45.15 | 26.95 | / | 10.16 | / | / | / | / | / | / | / | / | / | / |
| Mean | 21.3 | 4.01 | 89.31 | 22.47 | 13.82 | 9.80 | 3.12 | 66.37 | 29.93 | 15.17 | 11.50 | 2.97 | 64.38 | 19.99 | 19.10 | 15.52 | |
| SD | 5.2 | 2.64 | 66.26 | 12.36 | 6.71 | 5.26 | 2.07 | 39.92 | 26.36 | 18.48 | 9.12 | 1.38 | 36.61 | 9.35 | 10.43 | 4.59 | |
| Minimum | 10.8 | 1.10 | 17.78 | 5.00 | 5.40 | 2.20 | 0.70 | 13.30 | 4.10 | 1.20 | 1.10 | 0.76 | 14.44 | 2.50 | 12.20 | 10.85 | |
| Maximum | 37.1 | 13.00 | 317.20 | 57.27 | 28.87 | 22.07 | 8.70 | 156.98 | 106.60 | 61.40 | 29.30 | 5.00 | 122.00 | 37.90 | 34.25 | 24.70 | |
| aabsorbed dose per unit administered activity | Max/min | 3.5 | 11.82 | 17.84 | 11.45 | 5.35 | 10.03 | 12.43 | 11.80 | 26.00 | 51.17 | 26.64 | 6.58 | 8.45 | 15.16 | 2.81 | 2.28 |
btotal cumulative dose
np = not possible to calculate
/ = not performed