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. 2020 Jan 31;10:38. doi: 10.3389/fonc.2020.00038

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Copyright © 2020 Martínez-Barriocanal, Arango and Dopeso.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic regulation by PVT1. PVT1 recruits EZH2 polycomb group protein leading to promoter methylation and transcriptional repression of CDKN2A (p16) and CDKN2B (p15).