Table 2.
Meta-analysis of the association between periodontitis and the risk of anemia.
| Classification |
Number of subjects |
SMD (95% CI) | I2 (%) | P-value |
|---|---|---|---|---|
| HEMATOLOGICAL PARAMETERS | ||||
| Hb | 12 | −0.76 (−1.15, −0.37) | 89.9 | <0.01 |
| RBC | 11 | 0.69 (−1.09,−0.29) | 89.8 | <0.01 |
| HCT | 10 | −1.13 (−1.69, −0.57) | 93.4 | <0.01 |
| MCV | 11 | −0.16 (−0.32, −0.01) | 34.0 | 0.03 |
| MCH | 9 | −0.16 (−0.28,−0.04) | 0.00 | <0.01 |
| MCHC | 10 | –0.04 (–0.55, 0.47) | 93.6 | 0.88 |
| ESR | 4 | 0.63 (0.06, 1.19) | 79.9 | 0.03 |
| IRON BIOMARKERS | ||||
| Serum iron | 4 | –1.06 (–2.27, 0.15) | 96.3 | 0.09 |
| Ferritin | 4 | 0.75 (–0.39, 1.90) | 94.2 | 0.19 |
| Transferrin | 2 | −4.6 (−13.1, −3.90) | 98.4 | 0.02 |
| Hepcidin | 2 | 0.59 (0.05, 1.12) | 45.6 | 0.03 |
Bold means low heterogeneity in significance tests.
BL, radiographic bone loss; CAL, clinical attachment loss; CI, confidence interval.