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. 2020 Feb 6;10:2003. doi: 10.1038/s41598-020-58904-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic distribution of the CGCs that encode antitumor compounds. Presence of each CGC was determined by searching all the genomes for homologs of each of the genes comprising the CGCs using BLASTX²⁴ with a minimum e-value of 10⁻¹⁰. Sequences of individual genes in a CGC were obtained from DoBISCUIT⁵⁷ and were used as query sequences. Presence of the CGC was inferred if there were significant BLASTX hits for at least 90% of the individual genes within the CGC. The phylogenetic tree is identical to that used in Fig. 1.