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. 2020 Feb 6;10:2027. doi: 10.1038/s41598-020-58822-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) HA microneedle array mold fabrication process; (i) pouring of PDMS, (ii) placing the microneedle stamp on the PDMS solution, (iii) curing and removing the stamp from PDMS mold, (iv) pouring the prepared HA solution onto the mold, (v) drying the HA solution, and (vi) the completed microneedle array. (b) Optical images of the fabricated microneedle at the concentrations of different HA solution; (i) 1 wt%, (ii) 2 wt%, (iii) 3 wt%, and (iv) 4 wt%. (Scale bar = 300 μm) (c) Comparison of microneedle properties at different HA concentrations; (i) solid height (hs) and (ii) tip angle.