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. 2020 Jan 31;10:59. doi: 10.3389/fonc.2020.00059

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Copyright © 2020 Wang, Shen, Yao, Wang, Zhu and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The microenvironmental landscape of GBM. (A) The GBM associated antigens. HER2, Human epidermal growth factor receptor 2; EGFR, epidermal growth factor receptor; GD2, disialoganglioside 2; H3 K27M, mutated histone H3 K27M; IDH, isocitrate dehydrogenase; IL13Rα2, interleukin-13 receptor alpha 2; EphA2, ephrin-A2. (B) The Immunosuppressive GBM microenvironment. TNF-α, tumor necrosis factor α; PD-1, programmed death 1; TGF-β, transforming growth factor-β; Arg-1, arginase 1; GM-CSF, granulocyte-macrophage colony-stimulating factor; MCP-1, monocyte chemoattractant protein 1; SDF-1, stromal cell-derived factor 1; PKC, protein kinase C.