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. 2020 Jan 31;10:1626. doi: 10.3389/fphar.2019.01626

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Copyright © 2020 Xiao, Qu, He, Huang, Qiao, Li, Pan, Sui and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Jiang-Suan-Chu-Bi recipe (JSCBR) extracts protect THP-1 cells against monosodium urate (MSU)-induced inflammation by affecting the expression of proteins from the NOD-like receptor signaling pathway. (A) Effects of JSCBR extracts on ASC, caspase-1, IL-1β, and NLRP3 protein levels in MSU-induced THP-1 cells based on the western blotting assay; (B) Statistical analysis of the effects of JSCBR extracts on protein expressions levels. Data are presented as the mean ± SD (n = 3), **p < 0.01, ***p < 0.001, ****p < 0.0001 versus control group. ^## p < 0.01, ^### p < 0.001, ^#### p < 0.0001 versus model group. ^& p < 0.05, ^&&& p < 0.001, ^&&&& p < 0.0001 versus colchicine group.