Table 1.
Tumors where altered lipid droplets or expression of lipid droplet-associated proteins is observed.
| Tissue | Tumor type | PLINs expressiona | Lipid droplets | References |
|---|---|---|---|---|
| Brain | Human brain tumor | ND | + | 190 |
| Glioma | High PLIN3 | + | 46 | |
| ND | + | 191 | ||
| Breast/mammary gland | Apocrine carcinoma | Low PLIN3 | ND | 192 |
| High PLIN2 | + | 193 | ||
| High PLIN2 | ND | 194 | ||
| Carcinoma of the breast | ND | + | 195 | |
| ND | ND | 6,47 | ||
| Invasive ductal carcinoma | Low PLIN2 | − | 192 | |
| PLIN3b | − | 196 | ||
| Invasive lobular carcinoma | Low PLIN2 | − | 192 | |
| Cervix | Cervical dysplasia | High PLIN3 | − | 173,197 |
| Invasive carcinoma | High PLIN3 | − | 173,197 | |
| Colon | Colon Adenocarcinoma | High PLIN2 | + | 8,188 |
| High PLIN2 | ND | 110 | ||
| High PLIN2, PLIN3 | + | 192 | ||
| PLIN2 | ND | 187 | ||
| Hyperplastic Polyps | High PLIN2 | + | 198 | |
| PLIN2 | ND | 183 | ||
| Colorectal Cancer | PLIN2 | + | 92 | |
| Esophagus | Esophageal adenocarcinoma | PLIN2 | ND | 185 |
| Head and Neck | Mammary analog secretory carcinoma | PLIN2 | + | 199 |
| Sebaceous carcinoma of the tongue | High PLIN2 | + | 200 | |
| Kidney | Clear-cell renal carcinoma | PLIN1, PLIN2, PLIN3 | + | 192 |
| High PLIN2b | − | 175,201 | ||
| High PLIN2b | ND | 176 | ||
| High PLIN2b | + | 13 | ||
| High PLIN2 | + | 202 | ||
| High PLIN2b, PLIN1, PLIN3 | + | 203 | ||
| High PLIN3b | + | 172 | ||
| ND | + | 49 | ||
| Larynx | Laryngeal squamous cell carcinoma | PLIN2, PLIN3, PLIN1 | − | 192 |
| Liver | Cholangiocarcinoma | High PLIN2, low PLIN1 | NC | 192 |
| Hepatocellular carcinoma | High PLIN2, low PLIN1 | + | 192 | |
| High PLIN2b | − | 204 | ||
| ND | + | 205 | ||
| Clear-cell hepatocarcinoma | ND | + | 206,207 | |
| Adrenal rest tumor | ND | + | 208 | |
| Lung | Large cell lung carcinoma | High PLIN2, PLIN3 | + | 192 |
| Lung adenocarcinoma | High PLIN3 | + | 192 | |
| High PLIN2 | ND | 168 | ||
| High PLIN2 | + | 174 | ||
| Lung squamous cell carcinoma | High PLIN2, PLIN3 | + | 192 | |
| Sarcomatoid/pleomorphic lung carcinoma | PLIN2 | ND | 168 | |
| Low PLIN2, high PLIN3 | − | 192 | ||
| Lymphoma | Burkitt lymphoma | PLIN2b | + | 209 |
| Malignant lymphoma | ND | ND | 7 | |
| Ovary | Ovarian adenocarcinoma | ND | + | 210 |
| Clear-cell carcinoma | ND | + | 211 | |
| Pancreas | Pancreas ductal adenocarcinoma | PLIN2, PLIN3, PLIN1 | − | 192 |
| Clear-cell gastrinoma | ND | + | 212 | |
| Prostate | Prostate gland adenocarcinoma | PLIN2, PLIN3, PLIN1 | NC | 192 |
| Prostate carcinoma | ND | + | 21,48,50 | |
| Skin | Apocrine-eccrine carcinoma | PLIN2, low PLIN1 | + | 213 |
| Basal cell skin carcinoma | High PLIN2, low PLIN3 | + | 192 | |
| PLIN2 | − | 214 | ||
| Low PLIN2 | − | 215 | ||
| Cutaneous apocrine carcinoma | Low PLIN2 | ND | 194 | |
| Cutaneous melanoma | PLIN2 | ND | 171 | |
| Sebaceous adenoma | High PLIN2, PLIN1 | − | 192 | |
| PLIN2 | − | 214 | ||
| Sebaceous carcinoma | High PLIN2, PLIN3, PLIN1 | + | 192 | |
| PLIN2 | + | 214,215 | ||
| PLIN2, PLIN3, PLIN1 | + | 216 | ||
| PLIN1, PLIN2 | − | 213 | ||
| High PLIN2 | + | 217 | ||
| Low PLIN2, PLIN3 | − | 192 | ||
| Skin squamous cell carcinoma | PLIN2 | − | 213,214 | |
| Low PLIN2 | + | 215 | ||
| Stomach | Gastric adenocarcinoma | PLIN2 | + | 189 |
| PLIN2 | ND | 169,184 | ||
| ND | + | 182 | ||
| Stomach adenocarcinoma | PLIN2, PLIN3, PLIN1 | − | 192 | |
| Thyroid | Papillary thyroid carcinoma | High PLIN2 | + | 218 |
PLINs perilipin proteins isoforms, NC data presented by the author do not allow for a clear conclusion to be drawn, ND not determined.
aProtein detection and/or increased (High) or decreased (Low) expression when compared to non tumoral tissue/samples.
bAlteration of mRNA levels.