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. 2020 Feb 6;10:1984. doi: 10.1038/s41598-019-56877-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell adhesion- and ECM related-genes are significantly up-regulated upon Sox2 overexpression in Schwann cells. (a) Heat map of the normalized overlapping genes differentially expressed in four selected Sox2-positive Schwann cell clones (SC^Sox2/Cl1, SC^Sox2/Cl2, SC^Sox2/Cl3, SC^Sox2/Cl4) compared to the wild type (SC^wt). The top significantly up- and downregulated ECM-related genes are highlighted. (b) Venn diagram of differentially regulated genes in Sox2 clones. (c,d) Gene ontology (GO) enrichment analysis for biological process and cellular components for the up-regulated overlapping genes in four Sox2-positive clones (SC^Sox2/Cl1, SC^Sox2/Cl2, SC^Sox2/Cl3, SC^Sox2/Cl4). (e) Literature-derived network of ECM related genes involved in cell adhesion and migration showing Fn1 as a highly interconnected gene within the network. Probes with a p-adjusted < 0.002 and 2 < fold change (FC) <−2 were considered for the analysis.