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. 2020 Feb 6;10:2062. doi: 10.1038/s41598-020-59038-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MicroCT (µCT) reconstructions and quantification of bone volume at 12 weeks after implantation in mandibular defects of minipig. (a) 3D reconstruction of the defect areas filled with the empty scaffold. (b) Transverse µCT of the defect area with the empty scaffold. (c) µCT quantification of the relative residual soft tissue volume to the total volume (RV/TV, p = 0.1766).). (d) 3D reconstruction of the defect areas filled with the pADSC-seeded scaffold. (e) Transverse µCT of the defect area with the pADSC-seeded scaffold. (f) µCT quantification of bone volume to the total volume of the former defect area (BV/TV, p < 0.05). Green arrows represent the bone of the mandible. Red arrows represent the scaffold implanted in the critical size mandibular defect. Yellow arrow represents de novo bone formation in the critical size mandibular defect.