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. 2020 Feb 6;10:2062. doi: 10.1038/s41598-020-59038-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Timeline and graphical abstract of the experimental study. (a) Timeline and summary of the experiment. (b) Graphical abstract of the different working steps done in the experiment. Creating of the mandibular critical size defect, Fabrication of the scaffolds, isolation, cultivation and osteogenic differentiation of the cells, Implantation of cell-loaded scaffolds and healing, Radiographic, histological and immunohistochemical staining of the regenerated defects.