Table 4.
Pathological characteristics of the study samples.
| Research number | Pathology | EMT status | Vimentin score | eCadherin score | Size (cm) | Histological grade | Calcifications (Yes/No) | Molecular class (based on ER/PR/HER2 status) | Material for SAXS |
|---|---|---|---|---|---|---|---|---|---|
| EMT-1 | Breast cancer | EMT positive | 6 | 3 | 3.8 | 3 | No | HER2 | FFPE (dewaxed) × 2 |
| EMT-2 | Normal breast of EMT-1 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-3 | Fibroadenoma (benign tumour) | No | Formalin fixed × 2 | ||||||
| EMT-4 | Fibroadenoma (benign tumour) | No | Formalin fixed × 2 | ||||||
| EMT-5 | Normal breast of EMT-6 | No | Formalin fixed × 2 | ||||||
| EMT-6 | Breast cancer | EMT negative | 0 | 6 | 3.4 | 3 | No | HR | Formalin fixed × 2 |
| EMT-7 | Normal breast of EMT-8 | No | Formalin fixed × 2 | ||||||
| EMT-8 | Breast cancer | EMT negative | 0 | 6 | 3 | 3 | No | HR | Formalin fixed × 2 |
| EMT-9 | Breast cancer | EMT positive | 9 | 2 | 6 | 3 | No | TN | FFPE (dewaxed) × 2 |
| EMT-10 | Normal breast of EMT-9 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-11 | Breast cancer | EMT positive | 4 | 3 | 5.5 | 2 | No | HR | FFPE (dewaxed) × 2 |
| EMT-12 | Normal breast of EMT-11 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-13 | Breast cancer | EMT positive | 6 | 3 | 7 | 3 | No | TN | FFPE (dewaxed) × 2 |
| EMT-14 | Normal breast of EMT-13 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-15 | Breast cancer | EMT positive | 6 | 3 | 8.3 | 3 | No | TN | FFPE (dewaxed) × 2 |
| EMT-16 | Normal breast of EMT-15 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-17 | Breast cancer | EMT positive | 9 | 9 | 2.5 | 3 | No | TN | FFPE (dewaxed) × 2 |
| EMT-18 | Breast cancer | EMT negative | 0 | 6 | 1.5 | 2 | Yes | TN | FFPE (dewaxed) × 2 |
| EMT-19 | Breast cancer | EMT positive | 9 | 3 | 3.5 | 3 | No | TN | FFPE (dewaxed) × 2 |
| EMT-20 | Breast cancer | EMT positive | 9 | 9 | 3.5 | 3 | No | TN | FFPE (dewaxed) × 2 |
| EMT-21 | Breast cancer | EMT positive | 6 | 6 | 3.5 | 3 | No | TN | FFPE (dewaxed) × 2 |
| EMT-22 | Breast cancer | EMT positive | 0 | 3 | 5 | 3 | Yes | HR | FFPE (dewaxed) × 2 |
| EMT-23 | Breast cancer | EMT negative | 0 | 9 | 2 | 3 | No | HR | FFPE (dewaxed) × 2 |
| EMT-24 | Normal breast of EMT-23 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-25 | Breast cancer | EMT negative | 0 | 9 | 4 | 2 | No | HR | FFPE (dewaxed) × 2 |
| EMT-26 | Normal breast of EMT-25 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-27 | Breast cancer | EMT negative | 0 | 9 | 2.7 | 3 | No | HR | FFPE (dewaxed) × 2 |
| EMT-28 | Normal breast of EMT-27 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-29 | Breast cancer | EMT negative | 0 | 9 | 4 | 3 | Yes | HER2 | FFPE (dewaxed) × 2 |
| EMT-30 | Normal breast of EMT-30 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-31 | Breast cancer | EMT negative | 3 | 9 | 1.5 | 1 | Yes | HR | FFPE (dewaxed) × 2 |
| EMT-32 | Normal breast of EMT-32 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-33 | Breast cancer | EMT negative | 0 | 6 | 2.5 | 3 | Yes | HER2 | FFPE (dewaxed) × 2 |
| EMT-34 | Normal breast of EMT-33 | No | FFPE (dewaxed) × 2 | ||||||
| EMT-35 | Breast cancer | EMT negative | 3 | 6 | 5 | 3 | N | HER2 | FFPE (dewaxed) × 2 |
Key:
EMT status: EMT positive = vimentin scores 6 to 9 and/or ecadherin score 0 to 4; EMT negative = vimentin score 0 to 4 and/or ecadherin score 6 to 9.
Histological grade is according to modified Bloom and Richardson system.
Molecular class: HR = Positive for ER and PR irregardless of HER2 expression; HER2 = HER2 enriched (IHC score 3 or confirmed amplifed by ISH) and negative for ER and PR; TN = Triple negative i.e. negative for ER, PR and not HER2 enriched.