Table 1.
Characteristics of the included studies.
| Study & Year | Nation | No. of patient (M/F) | Age (yr),mean (range) | Patient enrollment | No. of lesion | Study design | Blind | Analysis method | Reference standard |
|---|---|---|---|---|---|---|---|---|---|
| Brendle (2016) | Germany | 15 (9/6) | 45 (10–62) | C | 37 | Retro | Y | Qualitative | H/IF |
| Cantwell (2008) | USA | 33 (22/11) | 63 | NC | 110 | Retro | Y | Semiquantitative | H/IF |
| Chiaradia (2014) | France | 15 (8/7) | 64 (38–88) | C | 79 | Retro | Y | Quantitative & Qualitative | H |
| Cho (2015) | Korea | 65 (35/30) | 66.6 | NR | 121 | Retro | NR | Qualitative | H/IF |
| Colagrande (2016) | Italy | 54 (35/19) | 69.5 (47–75) | NC | 135 | Retro | Y | Qualitative | IOUS & H |
| Hwang (2018) | Korea | 175 (115/60) | 59.3 | C | 474 | Retro | Y | Semiquantitative | H |
| Kartalis (2011) | Sweden | 15 (7/8) | 64 ± 8 | NR | 40 | Retro | Y | Qualitative | H/IF |
| Kong (2008) | UK | 65 (42/23) | 65* | NR | 171 | Retro | Y | NR | H/IF |
| Mainenti (2010) | Italy | 34 (20/14) | 63 (29–81) | C | 57 | Retro | Y | Qualitative | BP/IOUS/H/IF |
| Oba (2018) | Japan | 59 (42/17) | 59 (30–81) | C | 275 | Retro | Y | NR | H/IF |
| Rappeport (2007) | Denmark | 35 (16/19) | 62* (33–74) | C | 124 | Pro | Y | Qualitative | H/IF/IOUS |
| Rojas (2014) | Italy | 51 (31/20) | 65* (28–79) | NC | 156 | Retro | NR | Qualitative | H |
| Said (2000) | USA | 19 (12/7) | 53 (32–73) | NR | 39 | NR | Y | Qualitative | H |
| Schulz (2016) | Norway | 46 (29/17) | 67* (33–85) | NR | 336 | Pro | Y | Qualitative | H/IF |
| Shiozawa (2017) | Japan | 69 (46/23) | 66 (34–86) | NR | 133 | NR | Y | Semiquantitative | H/IF |
| Sivesgaard (2018) | Denmark | 80 (47/33) | 68* (29–86) | C | 533 | Pro | Y | Semiquantitative | H/IF/IOUS/CE-CT |
| Zerhouni (1996) | USA | 166(NR) | NR | NR | 459 | NR | Y | Semiquantitative | H/IF |
*Median age; BP: bimanual palpation; C: consecutive; CE-CT: contrast-enhanced computed tomography; H: histopathology; IF: imaging follow–up; IOUS: intraoperative ultrasonography; NC: non-consecutive; NR: not reported; Pro: prospective; Retro: retrospective; Y: yes.