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. 2019 Dec 27;16:100–110. doi: 10.1016/j.omto.2019.12.007

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Cytotoxicity of CM082 on ABCB1 and ABCG2-Overexpressing Cells and Their Parental Drug-Sensitive Cells

(A) The structure of CM082. (B) Cytotoxicity assay of CM082 in ABCB1 overexpression KBv200 cells and their parental drug-sensitive KB cells. (C) Cytotoxicity assay of CM082 in ABCG2 overexpression H460/MX20 cells and their parental drug-sensitive H460 cells. (D) Cytotoxicity assay of CM082 in S1 and S1-MI-80 cells. (E) Cytotoxicity assay of CM082 in HEK293/pcDNA3.1 and stable transfected ABCG2-R482T (mutant) cells. (F) Cytotoxicity assay of CM082 in HEK293/pcDNA3.1 and stable transfected ABCG2-R482 (wild-type) cells. Results from three independent experiments are expressed as the mean ± SD.