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. 2019 Dec 27;16:100–110. doi: 10.1016/j.omto.2019.12.007

Figure 4.

Figure 4

The Inhibition of [125I]-IAAP Photoaffinity Labeling, the Stimulation of ATPase Activity of ABCG2, and the Decrease of Rho 123 Efflux Were Induced by CM082

(A) In course of time, the change of Rho 123 efflux was determined in S1-MI-80 cells and S1 cells with 5 μM CM082 or not. (B) The ATPase activity of vanadate-sensitive ABCG2 under the indicated concentrations of CM082 was assessed. (C) The relative amount of [125I]-IAAP that was incorporated to the ABCG2 protein was plotted against the concentration of CM082 used in the competition. 100% incorporation indicated that CM082 was vacant. The mean and standard error values are shown.