Table 1.
Demographic and clinical characteristics of the participants
| Characteristic | All | cHT |
cSBP |
cDBP |
Statistics* |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| HT+ | HT– | LSBP | NSBP | LDBP | NDBP | cHT | cSBP | cDBP | ||
| Number | 505 | 257 | 248 | 85 | 420 | 33 | 472 | |||
| Age (yr) | 73.8±6.3 | 75.0±6.2 | 72.6±6.0 | 73.7±6.4 | 73.9±6.2 | 75.8±6.0 | 73.7±6.3 | <0.001 | 0.866 | 0.059 |
| Female sex (%) | 60.0 | 61.5 | 58.5 | 60.0 | 60.0 | 60.6 | 60.0 | 0.490 | 1.000 | 0.941 |
| ICV (cc) | 1,562.0±156.9 | 1,548.2±157.1 | 1,576.2±155.7 | 1,591.8±160.4 | 1,555.9±155.6 | 1,594.4±160.8 | 1,559.7±156.5 | 0.045 | 0.055 | 0.220 |
| VWMH (cc) | 11.7±16.7 | 13.7±18.4 | 9.5±14.5 | 14.6±21.1 | 11.1±15.7 | 12.8±15.4 | 11.6±16.8 | 0.004 | 0.141 | 0.691 |
| VPVWMH (cc) | 8.2±9.8 | 9.6±11.4 | 6.8±7.6 | 9.9±10.6 | 7.9±9.6 | 9.3±9.0 | 8.1±9.9 | 0.001 | 0.081 | 0.504 |
| VDWMH (cc) | 3.5±8.1 | 4.2±7.9 | 2.7±8.3 | 4.7±12.2 | 3.2±7.1 | 3.5±6.8 | 3.5±8.2 | 0.042 | 0.263 | 0.991 |
| Diabetes mellitus (%) | 20.6 | 26.5 | 14.5 | 20 | 20.7 | 24.2 | 20.3 | 0.001 | 0.882 | 0.592 |
| Hyperlipidemia (%) | 35.8 | 38.1 | 34.3 | 25.9 | 37.9 | 27.3 | 36.4 | 0.274 | 0.036 | 0.288 |
| BUN (mg/dL)† | 16.1±6.0 | 16.8±6.9 | 15.5±4.8 | 16.1±6.4 | 16.2±5.9 | 16.8±6.5 | 16.1±6.0 | 0.012 | 0.983 | 0.583 |
| Creatinine (mg/dL)† | 0.9±0.3 | 0.9±0.3 | 0.8±0.2 | 0.8±0.3 | 0.9±0.3 | 0.9±0.4 | 0.9±0.3 | 0.117 | 0.734 | 0.811 |
| Duration of hypertension (yr) | 5.7±8.9 | 11.3±9.7 | NA | 5.1±10.1 | 5.8±8.6 | 10.3±13.5 | 5.1±8.4 | - | 0.562 | 0.003 |
| SBP (mm Hg) | 122.7±10.1 | 124.1±9.9 | 121.2±10.2 | 106.3±5.4 | 126.0±7.3 | 106.2±10.0 | 123.8±9.1 | 0.001 | <0.001 | <0.001 |
| DBP (mm Hg) | 75.0±8.1 | 75.1±8.3 | 74.9±8.0 | 65.2±6.5 | 77.0±6.8 | 57.6±3.5 | 76.2±6.8 | 0.718 | <0.001 | <0.001 |
| Anti-hypertensive medication (n) | 0.8±0.9 | 1.5±0.8 | NA | 0.5±0.9 | 0.8±0.9 | 1.0±1.1 | 0.8±0.9 | - | 0.009 | 0.217 |
Values are presented as mean±standard deviation.
cHT, controlled hypertension; cSBP, current systolic blood pressure; cDBP, current diastolic blood pressure; HT+, controlled hypertension group; HT–, without history of hypertension; LSBP, low systolic blood pressure group; NSBP, not-low systolic blood pressure group; LDBP, low diastolic blood pressure group; NDBP, not-low diastolic blood pressure group; ICV, intracranial volume; Vwmh, volume of total white matter hyperintensity; Vpvwmh, volume of periventricular white matter hyperintensity; Vdwmh, volume of deep white matter hyperintensity; BUN, blood urea nitrogen; NA, not applicable; SBP, systolic blood pressure; DBP, diastolic blood pressure.
Student t-test was used for continuous variables and chi-square test for categorical variable;
n=484.