Table 1.

Thrombus composition and etiology of stroke

Study	Patient no.	Device	Staining method	Analysis (quantitation)	RBC-dominancy	Fibrin/fibrin-plateletdominancy	Leukocytes
Marder et al. (2006) [9]	25	Merci	H&E	Feature detection analysis	No differences between etiologies	No differences between etiologies
Liebeskind et al. (2011) [10]	50	Merci	H&E	Semi-automated	No differences between etiologies	No differences between etiologies
Sato et al. (2012) [18]	17	Autopsy	IHC (fibit for fibrin, platelet glycoprotein IIbIIIa for platelets, glycophorin A for RBC	Semi-automated	Cardiac	No differences between etiologies
Niesten et al. (2014) [11]	22	Merci, Trevo, solitaire	H&E, Mallory’s phosphotungstic acid-hematoxylin (fibrin)	Consensus	Arterial dissection	No differences between etiologies
			IHC (glycophorin A for RBC, CD31 for platelets)
Kim et al. (2015) [12]	37	Solitaire, aspiration	H&E	Semi-automated	Cardiac	Arterial (fibrin)	No difference
			IHC (CD61 for platelets)			No difference (platelet)
Ahn et al. (2016) [13]	32	Aspiration	H&E, MSB, IHC (CD42b for platelets)	Semi-automated	Arterial	Cardiac (fibrin)	Cardiac
						Cryptogenic
Boeckh-Behrens et al. (2016) [14]	137	Not specified	H&E, Elastica van Gieson	Semi-automated	Noncardiac	Cardiac (fibrin-platelet)
						Cryptogenic
Boeckh-Behrens et al. (2016) [17]	34	Solitaire, Trevo, Penumbra Pulse	H&E, Elastica van Gieson	Semi-automated	ND	ND	Cardiac
Sporns et al. (2017) [19]	187	pRESet stent retriever	H&E, Elastica van Gieson, Prussian blue	Semi-automated	Noncardiac	Cardiac (fibrin)	Cardiac
			IHC (CD3, CD20, CD68)			Cryptogenic
Maekawa et al. (2018) [16]	79	Solitaire, Trevo, Revive, Penumbra	HE	Semi-automated	Arterial Cryptogenic	Cardiac (fibrin)	No difference

RBC, red blood cell; H&E, hematoxylin and eosin; IHC, immunohistochemistry; MSB, Martius scarlet blue; ND, no description.