Table 3.
The hippocampal profile of the three groups. ALSFRS-r = the revised ALS functional rating scale, EMM = estimated marginal mean, M = Mean, N/a = Not applicable, SE = standard error, SD = standard deviation. Estimate marginal means are adjusted with the following values age = 58.77, gender = 1.45, education = 13.78, and total intracranial volume = 1429699.38.
| PLS n = 33 |
ALS n = 100 |
Healthy Controls n = 117 |
p value | |
|---|---|---|---|---|
| CA1 (mm3) EMM/SE | 632.8 (10.8) | 642.2 (6.2) | 660.5 (5.8) | 0.03 |
| CA2/CA3 (mm3) EMM/SE | 214.1 (5.0) | 212.6 (2.9) | 227.6 (2.7) | 5.2E-4 |
| CA4 (mm3) EMM/SE | 254.6 (4.6) | 257.0 (2.6) | 270.0 (2.5) | 4.2E-4 |
| Fimbria (mm3) EMM/SE | 74.9 (2.9) | 75.6 (1.6) | 77.1 (1.5) | 0.72 |
| Subiculum (mm3) EMM/SE | 421.6 (7.4) | 428.9 (4.3) | 438.7 (4.0) | 0.08 |
| Molecular layer (mm3) EMM/SE | 559.5 (9.3) | 563.5 (5.4) | 589.3 (5.0) | 6.5E-4 |
| GC-ML-DG (mm3) EMM/SE | 292.3 (5.4) | 296.5 (3.1) | 311.8 (2.9) | 2.9E-4 |
| HATA (mm3) EMM/SE | 62.7 (1.5) | 62.2 (0.9) | 65.1 (0.8) | 0.04 |