Table 2.

Summary of Gaps and Future Directions

•Anchor phenotypic clusters to clinically meaningful outcomes, including patient-centered measures (eg, quality of life, function) •Assess reproducibility and stability of phenotypic clusters within and across study cohorts •Harmonize methods for assessment of features used in cluster analyses •Incorporate novel features with mechanistic implications (eg, physiologic OSA traits, hypoxic burden, arousal intensity) •Evaluate biomarker profiles within phenotypic subtypes and incorporate them into multi-domain analyses •Develop simple prediction tools for OSA subtypes with clinical implications •Include broad age ranges, women and racial/ethnically diverse participants in future studies