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. 2020 Feb 3;52:102636. doi: 10.1016/j.ebiom.2020.102636

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 2 — Proteomic analysis of PDE6A human vitreous. (a–b) Pars plana vitrectomy and epiretinal membrane (ERM) removal procedure for an PDE6A (arRP) patient (II:5 in Fig. 1). A vitreous biopsy was collected from this patient and the affected brother. Protein content was analyzed by LC-MS/MS. The vitreous cutter is denoted by the letter ‘v.’ (c) Protein spectral counts were analyzed by 1-way ANOVA. Results are represented as a volcano plot. The horizontal axis (x-axis) displays the log2 fold-change value (arRP vs. ERM) and the vertical axis (y-axis) displays the noise-adjusted signal as the -log10 (p-value) from the 1-way ANOVA analysis. Increased levels of FASN and IGFBP2 are denoted by the orange circles. Blue circles indicate decreased levels of MFAP4 and APLP2 in arRP vitreous compared to controls.