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. 2020 Feb 3;52:102636. doi: 10.1016/j.ebiom.2020.102636

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 3 — Proteomic analysis of Pde6ɑ^D670G retina and vitreous at early-, mid-, and late-stage retinitis pigmentosa (RP). (a) Timeline of the clinical disease presentation in Pde6ɑ^D670G mice. (b) Histological analysis of Pde6ɑ^D670G mouse retinas at early-(P11), mid-(P30) and late-(P72) stage disease compared to a wild-type mouse at (P12) shows loss of the ONL photoreceptor cells over time. RPE, retinal pigment epithelium; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer. Scale bar = 100 µm. (c) Protein spectral counts were analyzed by 1-way ANOVA followed by hierarchical clustering. A total of 1,384 proteins were differentially expressed in the Pde6ɑ^D670G vitreous and retina samples compared to controls (p < 0.05 [1-way ANOVA]). Results are represented as a heatmap and display protein expression levels on a logarithmic scale. Orange indicates high expression while dark green/black indicates low or no expression.