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. 2020 Feb 3;52:102636. doi: 10.1016/j.ebiom.2020.102636

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig 4 — Proteomic analysis of Pde6ɑ^D670G retina and vitreous identifies global protein expression changes. (a) Protein spectral counts were analyzed by 1-way ANOVA followed by hierarchical clustering. A total of 1,067 proteins were differentially expressed in the Pde6ɑ^D670G vitreous and retina samples (when comparing protein expression profiles at P15 only) compared to controls (p < 0.05 [1-way ANOVA]). Results are represented as a heatmap and display protein expression levels on a logarithmic scale. Orange indicates high expression while dark green/black indicates low or no expression. Pde6ɑ^D670G vitreous samples are highlighted by the red font. There were 446 proteins that were depleted in the Pde6ɑ^D670G retina that were upregulated in the Pde6ɑ^D670G vitreous. There were 41 proteins that were depleted in the Pde6ɑ^D670G vitreous compared to the control vitreous. (b) Pathway representation of the 446 candidate biomarkers in the Pde6ɑ^D670G vitreous. Pathways are ranked by their fold-enrichment obtained from the Mann–Whitney U Test. Metabolic and energetic pathways are denoted by bold-faced text.