Figure 1.

IU1 Treatment Resulted in Durable Tumor Regressions in p53-Deficient Mice

(A) Kaplan-Meier survival analysis was used to evaluate the treatment effect of IU1 in wild-type (WT), heterozygous p53^+/− mice, and homozygous p53^−/− mice for OS. (B–E) The effect of IU1 in WT, heterozygous p53^+/− mice, and homozygous p53^−/− mice on the whole body (B), time to detected tumor (C), tumor volume (D and E). Ctrl, control; Mock, mice without treatment; ND, not detected. Data shown are the mean ± SD. Statistical analyses were performed with one-way ANOVA (*p < 0.05 and **p < 0.01 versus control).