Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model Structure and Fit
(A) Schematic diagram of the modeled UPR pathway with both pharmacokinetics and signaling network.
(B) Model fits to the experimentally observed levels of pXBP1(S), ATF4, BiP, and CHOP upon tunicamycin exposure at five concentrations. Dots present values for three replicates. Optimized fits from models with ATF6 branch (solid curves) or without (dashed curves) are plotted.
