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. 2020 Jan 23;23(2):100860. doi: 10.1016/j.isci.2020.100860

Figure 4.

Figure 4

Model-Based Prediction of CHOP Transcription

(A) Illustration of the TFs contributing to CHOP transcription.

(B–D) Simulations of the contributions of pXBP1(S), ATF4, and pATF6(N) to the CHOP production rate after exposure to tunicamycin concentrations of 1 (B), 4 (C) and 6μM (D), respectively.

(E) Model prediction of CHOP levels within the first 24 h (solid line) and between 24 and 34 h (dashed line). Simulations were conducted with various strengths of exposure (between 30% and 130% of the reference value) shown as shaded areas.

(F) Image-based experimental observation of CHOP for 34 h represented as the mean ± SE of three biological replicates.