Figure 4.

Transient GFP Expression in Retina and Choroid after Suprachoroidal AAV8 Delivery in Rhesus Macaques

(A–C) Confocal fluorescence images with (D–F) magnified views of the white-dashed boxes in (A)–(C) showing GFP transgene expression in the retinal pigment epithelium (RPE) and sclera (green) co-immunostained with anti-RPE65 (red) to label RPE and with DAPI (blue) to label cell nuclei in eyes at 1 month (A and D), 2 months (B and E), and 3 months (C and F) after suprachoroidal (SC) injection of AAV8-GFP. Scale bars, 100 μm.