Figure 6.

Host Humoral Immune Responses after Suprachoroidal or Intravitreal AAV8 Injections in Rhesus Macaques

(A and B) Epifluorescence images of HEK293T cells incubated with macaque serum and AAV8-CMV-GFP to detect serum neutralizing antibodies (NAbs) before and after suprachoroidal (SC/SC) (A) or intravitreal (IVT/IVT) (B) AAV8 injections. (C and D) Line graphs comparing serum (C) and aqueous (D) NAb titers in each study animal after AAV8 injections. The AAV8 injection mode and dose are labeled in (C). IVT, intravitreal; SC, suprachoroidal; SR, subretinal.