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BiP level markedly elevated in a dose-dependent manner in rats pretreated with icariin compared to that in rats treated with CRH alone (A). IRE-1a protein expression in rats was obviously increased by CRH treatment and significantly reduced in the lung of asthmatic rats after each dose of icariin treatment (B). β-actin was reused from Figure 10 in the measurement of BiP. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. NC group; ##p < 0.01 and ###p < 0.001 vs. A group.
