Table 1.
Kinetic parameters for SARM‐2f in cynomolgus monkeys
|
Dose mg/kg/day |
Male (N = 2) | Female (N = 2) | Total (N = 4) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| T max | C max | AUC 0‐24 h | T max | C max | AUC 0‐24 h | T max | C max | AUC 0‐24 h | ||
| (h) | (ng/mL) | (ng·h/mL) | (h) | (ng/mL) | (ng·h/mL) | (h) | (ng/mL) | (ng·h/mL) | ||
| 10 | 1st | 1.0 | 2681 | 8188 | 1.0 | 3341 | 8116 | 1.0 ± 0.0 | 3011 ± 718 | 8152 ± 945 |
| 14th | 0.8 | 3176 | 8620 | 1 | 2297 | 6043 | 0.9 ± 0.3 | 2736 ± 525 | 7331 ± 1618 | |
Male and female cynomolgus monkeys were treated with SARM‐2 (10 mg/kg) single dose or daily oral administration for 14 consecutive days.
AUC0‐24 h, area under curve from time 0 to 24 h; C max, peak plasma concentration; T max, time at C max.