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. 2020 Jan 31;10:1775. doi: 10.3389/fpls.2019.01775

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Copyright © 2020 Barco and Clay

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interlinked coherent and incoherent type 1 feed-forward loops (FFLs) in ETI-responsive specialized metabolism. (A–B) Three FFLs identified in this study form a composite hierarchical network motif (A) that is likely responsible for the expression dynamics and metabolic flux changes through the camalexin and 4OH-ICN pathways (B). Blue and red directed lines indicate activating and inhibitory direct (solid) and indirect (dashed) interactions, respectively, between TFs (orange and blue circles in A, rectangles in B) and pathway genes (purple circles in A, arrows in B).