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Schematic figure of the Z‐line in the cardiomyocyte. PDLIM5 has a direct interaction with LDB3 and forms a complex together with calsarcin. They bind to α‐actinin‐2 on one side and to the filamin C‐complex at the other side. The large protein titin also binds to α‐actinin‐2. The patient described in our manuscript has a loss of function mutation in both TTN and PDLIM5 (as indicated by an asterisk)
