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. 2019 Dec 3;12(2):e10862. doi: 10.15252/emmm.201910862

Figure 1. MT1‐MMP expression in endothelial cells contributes to intussusceptive angiogenesis in colitis.

Figure 1

  • A
    Representative maximum‐intensity projection images of colon mucosal plexus in CD31‐stained (green) whole‐mount distal colon from MT1f/f and MT1iΔEC mice left untreated (basal) or treated with 1% DSS for 3 or 7 days. Scale bar, 40 μm. Arrows, arrowheads, and asterisks indicate duplications, loops, and pillars, respectively.
  • B
    Quantification of IA events in the colon mucosal plexus of mice treated as in (A), including vascular holes, duplications, and loops; n = 9–15 mice per genotype and condition. Data are shown as mean ± SEM and were tested by one‐way ANOVA with Benjamini and Hochberg post‐test; *P < 0.05, **P < 0.01.
  • C
    Quantification of vascular angles at the Y‐junctions in the colon mucosal plexus of mice left untreated or treated with 1% DSS for 3 days; n = 6 mice per genotype and condition. Data are shown as mean ± SEM and additionally as individual animal values and were tested by one‐way ANOVA with Benjamini and Hochberg post‐test; **P < 0.01.
Data information: Please see Appendix Table S3 for exact P‐values.Source data are available online for this figure.