Figure 6. MT1‐MMP absence in endothelial cells leads to perivascular accumulation of thrombospondin‐1 (TSP1) in the inflamed colon.

• A, B
  Representative maximum‐intensity projection images of staining for TSP1 (red) and CD31 (gray) in (A) and also for MT1‐MMP (green) in (B) in colon sections obtained from MT1^f/f and MT1^iΔEC mice left untreated (A) or treated with 1% DSS for 3 days (B). Magnified views are shown to the right. Scale bars, 100 μm in main panels and 10 μm in the magnified views.
• C
  TSP1 mean fluorescence intensity (MFI) in the perivascular area of large vessels present in the colon mucosa of treated mice, as depicted in (B); n = 4 mice per genotype. Data are shown as mean ± SEM and were tested by t‐test; *P < 0.05.

Data information: Please see Appendix Table S3 for exact P‐values.Source data are available online for this figure.