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. 2019 Dec 3;12(2):e10862. doi: 10.15252/emmm.201910862

Figure 9. Working model of the role of MT1‐MMP/TSP1/nitric oxide axis in IA during colitis.

Figure 9

The scheme depicts the role that endothelial cell MT1‐MMP (left) exerts in IA during colitis by processing TSP1 and binding of the generated TSP1 C‐terminal fragment to CD47/αvβ3 integrin, thus inducing nitric oxide production. This signaling cascade ultimately leads to arteriole vasodilation and endothelial cell intussusceptive remodeling in the capillary plexus of the inflamed intestinal mucosa. When MT1‐MMP is absent from endothelial cells (right), this pathway is impaired, IA reduced, and colitis ameliorated. EC, endothelial cell; P, pericyte; FB, fibroblast; Col, collagen.