Figure 3.

miR‐503‐5p was the target of circ_0000267 in GC. (a) Bioinformatics analysis predicted the binding site between miR‐503‐5p and circ_0000267. (b) Analysis of the correlation between the expression levels of circ_0000267 and miR‐503‐5p in 51 patients. (c, d) Dual luciferase reporter assay showed that miR‐503‐5p inhibited the luciferase activity of wild‐type circ_0000267, but the luciferase activity of mutant circ_0000267 was not changed significantly. (e) After upregulating MGC‐803 cells, circ_0000267, and knocking down circ_0000267 in SGC‐7901 cells, the expression level of miR‐503‐5p was detected by qRT‐PCR. **p < .01, ***p < .001