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. 2019 Oct 31;1(5):369–376. doi: 10.1016/j.jhepr.2019.10.003

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© 2019 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — The expression of TGR-5 is increased in chronic liver diseases.

The expression of TGR-5 was significantly higher in diseased livers than in NL and the pattern of expression was different within diseases, with PSC liver expressing a moderate level of TGR-5 when compared to other diseases (PBC, ALD and NASH); (A) Representative images for TGR-5 immunohistochemistry staining from different diseased livers and normal control (TGR-5, brown); (B) The pattern of TGR-5 expression in liver tissue from different sources; (C) Tissue taken from patients with PSC expressed lower levels of TGR-5 compared to other diseased livers. Expression was estimated as percent surface area using ImageJ. Data are represented as median ± IQR. One-Way ANOVA with multiple comparison was used for statistical analysis. ****p ≪0.001; ***p ≪0.005; *p ≪0.05.

ALD, alcohol-related liver disease; NASH, non-alcoholic steatohepatitis; NL, normal liver; PBC, primary biliary cholangitis, PSC, primary sclerosing cholangitis.