Fig. 5.

Frequency of TGR-5 expression by intrahepatic macrophages subsets.

(A) Representative FACS dot plot for TGR-5 expression on CD68⁺ (top panels) and CD68⁺CD206⁺ (bottom panels) intrahepatic macrophages. Isotype control (left) and TGR-5⁺ cells (right); (B) Bar chart representing percentages of TGR-5 expression on intrahepatic macrophage subsets; (C) Bar chart representing percentages (left) and MFI (right) of TGR-5 expression on CD68⁺ intrahepatic macrophages; (D) Bar chart representing percentages (left) and MFI (right) of TGR-5 expression on CD68⁺CD206⁺ intrahepatic macrophages. Data are represented as median ± IQR. Mann-Whitney U test was used for statistical analysis. **p ≪0.01, with respect to PSC. Other livers including PBC and ALD.

ALD, alcohol-related liver disease; MFI, mean fluorescence intensity; PBC, primary biliary cholangitis, PSC, primary sclerosing cholangitis.