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. 2019 Apr 1;33(8):1297–1304. doi: 10.1038/s41433-019-0409-z

Table 2.

Bilateral advanced (group D or E) intraocular retinoblastoma: tumor features and classification

Feature n (%)
n = 144
Orbital pseudocellulitis 3 (2)
Megalocornea 13 (9)
Secondary glaucoma 21 (15)
Pseudohypopyon 3 (2)
Hyphema 5 (3)
Iris neovascularization 23 (16)
Ectropion uveae 17 (12)
International Classification of Retinoblastoma (Philadelphia version)
  Group D 60 (42)
  Group E 84 (58)
  Bilateral group D 12 (8)
  Bilateral group E 24 (17)
  Combination of groups D and E 36 (25)
International Classification of Retinoblastoma (Children’s Hospital Los Angeles version)
  Group D 84 (58)
  Group E 60 (42)
  Bilateral group D 22 (15)
  Bilateral group E 10 (7)
  Combination of groups D and E 40 (28)
8th edition AJCC
  T2a 28 (19)
  T2b 88 (61)
  T3a 3 (2)
  T3b 1 (< 1)
  T3c 17 (12)
  T3d 4 (3)
  T3e 3 (2)
  Bilateral T2 45 (31)
  Bilateral T3 1 (< 1)
  Combination of T2 and T3 26 (18)

AJCC    American Joint Committee Classification