Table 3.
Bilateral advanced (group D or E) intraocular retinoblastoma: treatment and outcomes
| Feature | n (%) |
|---|---|
| n = 144 | |
| Primary treatment | |
| Systemic chemotherapy | 138 (96) |
| Enucleation | 6 (4) |
| Adjuvant treatment* | |
| Transpupillary thermotherapy | 66 (46) |
| Cryotherapy | 24 (17) |
| Periocular carboplatin | 19 (13) |
| Systemic chemotherapy | 2 (1) |
| External beam radiotherapy | 14 (10) |
| Secondary enucleation | 45 (33) |
| Secondary treatment* | |
| Transpupillary thermotherapy | 27 (19) |
| Cryotherapy | 18 (13) |
| Periocular carboplatin | 5 (3) |
| Plaque radiotherapy | 3 (2) |
| Intraarterial chemotherapy | 4 (3) |
| Systemic chemotherapy | 19 (13) |
| External beam radiotherapy | 1 (1) |
| Secondary enucleation | 11 (8) |
| Total number of chemotherapy cycles Mean (median, range) | 9 (6, 6–30) |
| Tumor recurrence | 42 (29) |
| Globe salvage | |
| Both eyes enucleated | 12 (17) |
| Both eyes salvaged | 23 (32) |
| One eye salvaged | 37 (51) |
| Visual acuity (n = 50 eyes) | |
| >20/200 | 24 (48) |
| <20/200 | 26 (52) |
| Second cancer | |
| Leukemia | 1 (1) |
| Pinealoblastoma | 1 (1) |
| Systemic metastasis | 3 (4) |
| Death | 4 (6) |
*Few patients needed more than one form of treatment