Table 5.

Globe salvage: Kaplan–Meier survival analysis based on tumor classification

Feature	Probability of globe salvage				p-value
Time point	Year 1	Year 3	Year 5	Year 10
Overall	70% ± 4%	60% ± 4%	55% ± 5%	44% ± 7%
International Classification of Retinoblastoma (Philadelphia version)
Group D	95% ± 3%	89% ± 4%	82% ± 6%	67% ± 11%	< 0.0001a
Group E	52% ± 6%	41% ± 6%	36% ± 6%	30% ± 7%
International Classification of Retinoblastoma (Children’s Hospital Los Angeles version)
Group D	94% ± 3%	88% ± 4%	78% ± 6%	62% ± 10%	< 0.0001b
Group E	36% ± 6%	21% ± 6%	21% ± 6%	21% ± 6%
8th edition AJCC
T2	83% ± 4%	74% ± 4%	69% ± 5%	56% ± 9%
T2a	74% ± 9%	69% ± 9%	63% ± 10%	63% ± 10%	0.59
T2b	86% ± 4%	76% ± 5%	71% ± 6%	46% ± 15%
T3	15% ± 7%	4% ± 4%	0%	0%	< 0.0001c

AJCC American Joint Cancer Committee

^aHazards ratio: 5.14; ^bhazards ratio: 8.26; ^chazards ratio: 11.87