Table 2.
Analytical performance of the e4Risk test prototype and the e4Risk test final formulation in 4 analyzers with different throughput capacity.
| Chemistry analyzer | e4Risk test prototype | e4Risk test | |||
|---|---|---|---|---|---|
| SpinLab 100 (Spinreact) | LIDA 300 (Linear Chemicals) | Architect c16000 (Abbott) | SK-500 (Tokyo Boekis) | Architect c16000 (Abbott) | |
| Throughput (tests/h) | 110 | 300 | 1600 | 580 | 1800 |
| N (APOE ε4 carriers) | 114 (59) | 103 (33) | 103 (33) | 118 (20) | 80 (15) |
| Sensitivity (%) | 100 | 100 | 100 | 100 | 100 |
| Specificity (%) | 94.8 | 95.9 | 97.3 | 98.9 | 98.5 |
| Accuracy (%) | 97.4 | 97.1 | 98.0 | 99.1 | 98.75 |
Accuracy is calculated as 1 minus misclassification rate.