Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 31;11:10. doi: 10.3389/fmicb.2020.00010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Martini, Moricz, Ripperger, Tran, Sharp, Forsythe, Kulhankova, Salgado-Pabón and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Pathology of distal organs is not significantly different among strains. Gross pathology of the kidney, liver, and lungs from infected rabbits. Representative images of (A) WT, (B) mur2, and (C) SSA_1099. The pathology scale used for scoring (Supplementary Figure S4) was derived from Kulhankova et al., (unpublished), and organs were scored by three blinded investigators. (D) Mutant strains did not exhibit distinct organ pathology compared to WT. Kidneys and liver exhibited moderate pathology on average, characterized by rare, small lesions evident on the surface. By contrast, lungs generally exhibited more severe pathology characterized by multifocal hemorrhaging and necrosis evident on one or both lobes. Statistical analysis was performed using two-way ANOVA against the WT mean and controlling for the FDR. Error bars represent the standard error.