TABLE 1.
Summary of S. sanguinis genes identified using in vitro assays.
| Gene designation | Known or putative function | Biofilm | Platelet Adh | Platelet Agg | HAEC Adh | HAEC Inv |
| pcsB | Peptidoglycan hydrolase | − | + | + | − | − |
| adcC | ABC transporter, Zn porter | − | − | − | + | + |
| SSA_0647 | Inorganic ion transport | − | − | − | + | − |
| srpA | Platelet-binding glycoprotein | − | + | + | − | − |
| SSA_0837 | Glycosyltransferase | − | + | + | − | − |
| SSA_0841 | Accessory secretory protein | − | + | − | − | − |
| murN | Peptidoglycan cross-linking | − | + | ± | − | − |
| SSA_0874 | Metabolite efflux | + | − | + | − | − |
| SSA_0907 | Fibronectin-binding protein A | − | − | + | + | + |
| SSA_1063 | Peptidoglycan-binding, vWFA-domain protein | − | − | − | + | + |
| mur2 | Peptidoglycan hydrolase | + | − | − | ± | − |
| SSA_1099 | RTX-like adhesin | ± | + | + | − | − |
| SSA_1101 | RTX export component | − | + | − | − | − |
| SSA_1129 | Iron transport lipoprotein | − | + | + | − | − |
| srtA | Sortase A | − | + | + | − | − |
| SSA_1515 | Cell wall polysaccharide | ± | − | − | − | − |
| hlyX | CBS domain adhesin | − | + | + | − | − |
| nrdD | Anaerobic ribonucleoside-triphosphate reductase | − | + | + | − | − |
Genes with novel associations to virulence-related phenotypes are colored light blue. +, phenotype; −, no phenotype; ±, intermediate phenotype.