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. 2020 Feb 7;10:2103. doi: 10.1038/s41598-020-58872-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of the (-)-hopeaphenol analogues on P. aeruginosa infection. J774 cells were infected with wild-type P. aeruginosa strain PAK and compounds were added and the T3SS dependent cell survival was analysed using a viability staining method. As controls uninfected cells, cells infected with the PAKpcrV-mutant and cells infected with the wild-type strain (PAK) were used. The survival was calculated as percenteage of the uninfected control. Samples were run in triplicates and the experiment were repeated three times. Viniferifuran (8) and dehydro-δ-viniferin (10) were very toxic at 100 µM, while some toxicity could be seen for resveratrol-pinceatannol hybrid (12). The graph shows the mean value (n = 3) +/−SD after 6 h of infection.