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. 2020 Feb 7;10:2141. doi: 10.1038/s41598-020-59082-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PET analysis of radiolabelled scFv- and IgG4-based α-GD2 TMs in vivo. TMs were modified with the chelator NODAGA and radiolabelled with ⁶⁴Cu yielding (A) [⁶⁴Cu]Cu-NODAGA-α-GD2 scFv or (B) [⁶⁴Cu]Cu-NODAGA-α-GD2 IgG4-based TM, which were intravenously injected into NMRI-Foxn1^nu/nu mice. Subsequently, PET scanning was performed at several time points. Coronal sections of the mice are shown. In addition, dynamic PET scans were performed over a period of 50 hrs. Time curves were constructed using mean activity concentration (SUV (g/ml)) in (C) blood, (D) liver, (E) kidneys, and (F) skin. SUV, standardized uptake value; p.i., post-injection.