Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 7;10:2141. doi: 10.1038/s41598-020-59082-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Specific cytotoxicity of UniCAR NK-92 cells redirected by α-GD2 TMs towards neuroblastoma cells. (A) UniCAR 28/ζ NK-92 cells were incubated with GD2-positive JF Luc neuroblastoma cells in the absence or presence of α-GD2 scFv or IgG4 TMs at an effector to target (E:T) ratio of 5:1. UniCAR stop and EGFP-expressing NK-92 cells (Vector control) were included as a control. (B) UniCAR 28/ζ NK-92 cells were co-cultured with JF Luc cells at different E:T ratios in the presence or absence of the indicated TMs for 4 hrs. Thereafter, specific lysis was measured using a luminescence-based assay. Results are shown as mean ± SD of triplicate samples (A) or data from two independent experiments (B).