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. 2020 Feb 7;10:2168. doi: 10.1038/s41598-020-58901-y

Figure 1.

Figure 1

Mature Asic5 KO mice exhibit ataxic behavior. Summary graphs of mean fall speeds (A) and fall times (B) for trained mature wild type (black bars) and Asic5 KO (gray bars) mice as quantified using an accelerating rotarod test. Balance beam test: Summary graphs comparing the mean number of slips per step taken (C), steps taken per crossing (D), and total time taken to cross (E) for trained mature littermate control (black bars) and Asic5 KO (gray bars) mice during a full run on an elevated horizontal balance beam. Summary data for both experiments from 10 different male littermate (83.0 ± 3.0 days old, 27.1 ± 0.5 g) and 10 different male Asic5 KO (90.5 ± 0.5 days, 25.8 ± 0.6 g) mice where each mouse was tested once in triplicate. *Significantly different using a two tailed unpaired t-test.