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. 2020 Feb 7;10:2168. doi: 10.1038/s41598-020-58901-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Asic5 influences the inherent excitability of type II UBCs. (A) Representative traces of typical action potential trains in current-clamped type II UBCs in vestibulocerebellar slices from wild type (top) and Asic5 KO (bottom) mice evoked by 200 msec 40 pA supra-threshold current injections. Summary graphs of mean resting membrane potentials (B) and membrane resistances (C) in current-clamped type II UBCs from wild type (black bars, n = 32, 15–20 slices, 5 animals, mean age P19) and Asic5 KO (gray bars, n = 28, 12–15 slices, 4 animals, mean age P18) mice. No value is significantly different. Summary graphs of mean firing frequencies (D) and interspike intervals (E) for action potentials evoked by current injections in current-clamped type II UBCs in vestibulocerebellar slices from wild type (black circles, n = 32, 5 animals) and Asic5 KO (gray boxes, n = 28, 4 animals) mice. Inset in E shows an enlarged area for significantly different values for interspike intervals evoked by current injections greater than 65 pA. Significantly different at *P < 0.05 and **P < 0.01 with t-test.